How Synthesa Uses AI to Reinvent Systematic Reviews: Step-by-Step with ChatGPT
At Synthesa, Inc., we are not just building AI-powered evidence synthesis tools — we are also helping define the future methods of AI-assisted systematic reviews.
In our latest featured publication, our co-founder Lefteris Teperikidis and colleagues published a comprehensive step-by-step tutorial in Minerva Cardiology and Angiology, describing how to conduct a systematic review using ChatGPT. This work reflects the foundational thinking that inspired Synthesa’s approach to combining large language models (LLMs) with clinical research expertise.
The tutorial breaks down every step of a systematic review and shows where ChatGPT can assist:
– Formulating the research question using PICOS criteria
– Designing PubMed search strategies, with ChatGPT generating and iteratively refining search strings
– Screening abstracts for inclusion/exclusion
– Generating structured summaries of each eligible study
– Building data extraction tables automatically from the summaries
– Assisting with risk of bias assessments, using validated tools like AMSTAR 2.0
This tutorial highlights what we at Synthesa believe is the future of evidence synthesis:
🔹 AI accelerates the manual processes that slow down traditional reviews.
🔹 Experts remain essential for oversight, interpretation, and final decision-making.
🔹 The human-AI partnership is key — AI speeds up the process, but humans ensure scientific rigor.
At Synthesa, we are turning these research lessons into real-world solutions. Our tools are being designed to automate what can be automated while preserving expert judgment where it matters most. This is how we aim to make systematic reviews faster, smarter, and more adaptive to emerging evidence — without compromising quality.
Read the full tutorial here: https://pubmed.ncbi.nlm.nih.gov/39056432/
This post is part of our ongoing series showcasing the research foundation behind Synthesa’s technology. Stay tuned for more as we continue to share the science that powers our platform.
